RNA Details
Disease Name
cardiomegaly
Tissue
heart
RNA Symbol
mir-15a
RNA ID
RNA Type
miRNA
Alteration Pattern
up regulation
Species
mus musculus
Detection Methods
PCR; Masson's trichrome staining etc.
Target
TGFBRI;SMAD3;SMAD7;P53
Pathway
P53 SIGNALING PATHWAY;TGF-BETA SIGNALING PATHWAY
PubMed ID
Title
The microRNA-15 family inhibits the TGFB-pathway in the heart
Year
2014
Function
"miRNA-15 family,inhibits the TGF-beta-pathway by targeting of TGF-betaR1 and several other genes within this pathway directly or indirectly, including p38, smad3, smad7, and endoglin, miR-16 family as a novel regulator of cardiac hypertrophy and fibrosis acting by inhibition of the TGF-pathway."